How to deliver cancer inspection devices to cells

I was reading through the archives How to Deliver New Enzymes to Clean Up Aged Cells.

The above blog article was about this paper New Strategies for Enzyme Replacement Therapy for Lysosomal Storage Diseases. It struck me that this could be a general way for getting “DNA Nanobots” inside cells in order to examine the DNA or mRNA to see if they are cancerous. Why is that important. Well I viewed the recent google X video on DNA nanobotsM and the presenter said solving cancer required drugs/treatments that were both specific and dealt with evolved resistance. He said the DNA nanaobots could examine the cells for cancer markers on their surfaces, then deliver 5 drugs at once… but what if the cancer cells evolve resistance by getting rid of the cell surface markers that the DNA Nanobots use? Or can they not do this?

Or could cancer cells just evolve resistance by getting rid of the mRNA that the now intra-cellular Nanobots are looking for? Would this be as easy as getting rid of cell surface markers?

Questions, questions

A lot of this blog will just be comments on the excellent blog by Reason.

I find that after reading articles on there my mind immediately has a couple of unanswered questions. Usually to do with how near the technology is to fruition. Or what the remaining problems facing a technology are. I usually search around the web for answers for a bit, often not finding any.

But rather than just posting the questions in comments below the fightaging! articles. I may post them here as well, then post up any answers or information that I later find out.

Fightaging made a post that work on Allotopic Expression of Mitochondrial Genes is Spreading.

My comment was:

That is very good news that this research is spreading.

Does anyone know if:

1 ~ The use of a targeting sequence to get the protein into the mitochondria is the same approach as that being studied by Matthew O’Conner and the SENS foundation?

2 ~ Looking at Matthew “Oki” O’Conner request for funding from I see that ND4 is part of Complex 1 which unfortunately has 6 other proteins from genes kept in the mitochodria rather than the nucleus. Will this approach work for the other 6 proteins in complex 1? What is to stop this working for all 13 proteins/genes?

Lets see what answers I can find…